Norman Koren mentioned this issue in his review of the Canonscan 4000:
http://www.normankoren.com/Tutorials/Canoscan4000.html
He recommends doing processing using a program called Picture Window
Pro, which retains full resolution for all operations. I haven't tried
this yet, but am planning to do so, since I've run into the same problem.
Mark.
Alan Harper wrote:
>I have a 16 bit scan of a photo that's on the large side (10,000 x
>7,000 pixels), and I want to see if it benefits from sharpening.
>Photoshop seems to be unable to sharpen a 16-bit image. I tried to
>"scan from disk" in Vuescan and use the sharpening there (and also
>tried grain reduction). Vuescan may have improved these aspects of
>the photo, but the exposure and saturation went completely kerflooy
>(a technical term meaning awful). Anyone have some guidelines for
>settings for Vuescan that will apply sharpening and/or grain
>reduction, but not change the exposure, color, etc at all?
>
>If not, I'll continue in Photoshop.
>
>Vuescan for Mac OS-X if that matters.
>
>Alan
>
>
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